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Great Plague

Great Plague

The Great Plague (AD 1665-1666) was a massive outbreak of disease in Britain that killed 75,000 to 100,000 people, up to a fifth of London's population. The disease is generally believed to have been bubonic plague, an infection by the bacterium Yersinia pestis, transmitted via a rat vector. Other symptom patterns of the bubonic plague, such as septicemic plague and pneumonic plague were also present. The 1665-66 epidemic was on a far smaller scale than the earlier "Black Death", a virulent outbreak of disease in Europe between 1347 and 1353, but was remembered afterwards as the "great" plague because it was one of the last widespread outbreaks in Europe.

Outbreak

This episode of plague in Britain is thought to have arrived with Dutch trading ships carrying bales of cotton from Amsterdam. The disease had occurred intermittently in the Netherlands since 1654. The dock areas outside of London, where poor workers crowded into ill-kempt districts, such as the parish of St. Giles-in-the Fields, were first struck by the plague. During the winter of 1664-65, there were reports of several deaths. However, the winter was very cold, seemingly controlling the contagion. But spring and summer months were unusually warm and sunny, and the plague spread rapidly. Records were not kept on the deaths of the very poor, so the first recorded case was Margaret Porteous, on April 12, 1665. By July 1665, plague was in the city of London itself. King Charles II of England, his family and his court left the city for Oxford. However, the Lord Mayor of the city and the aldermen stayed at their posts. Businesses were closed when most wealthy merchants and professionals fled. Only a small number of clergymen, physicians and apothecaries chose to remain, as the plague raged throughout the summer. Several public health efforts were attempted. Physicians were hired by city officials, and burial details were carefully organized. Authorities ordered fires to be kept burning night and day, in hopes that the air would be cleansed. Substances giving off strong odors, such as pepper, hops or frankincense, were also burned to ward off the infection. London residents, including young children, were strongly urged to smoke tobacco. Though concentrated in London, the outbreak affected other areas of the country. Perhaps the most famous example was the village of Eyam in Derbyshire. The plague arrived in a parcel of cloth sent from London. The villagers imposed a quarantine on themselves to stop the further spread of the disease. Spread of the plague was slowed in surrounding areas, but the cost to the village was the death of around 50% of its inhabitants. Records state that deaths in London crept up to 1000 persons per week, then 2000 persons per week and, by September 1665, to 7000 persons per week. By late fall, the death toll began to slow until, in February 1666, it was considered safe enough for the King and his entourage to return to the city. By this time, however, trade with the European continent had spread this outbreak of plague to France, where it died out the following winter. Plague cases continued at a modest pace until September 1666. On September 2nd and 3rd, the Great Fire of London destroyed many of the most crowded housing and business areas of the city, causing 16 deaths. This event seems to have effectively stopped the plague outbreak, probably due to the destruction of London rats and their plague-carrying fleas. After the fire, London was rebuilt on an urban plan originally drafted by architect Christopher Wren which included widened streets, reduced congestion and basic sewage-drainage systems. Thatched roofs (which had provided splendid places for rats to live) were also forbidden within the city, and remain forbidden under modern codes. The second rebuilding of the Globe Theatre in 1997 required a special permit to have a thatched roof.

Literary accounts

Accounts of the plague were given by Samuel Pepys in his famous diary, and by Daniel Defoe in the fictional work A Journal of the Plague Year, published in 1722. In some people, wrote Defoe, "...the plague swellings ... grew so painful ... not able to bear the torment, they ... threw themselves out of windows. Others, unable to contain themselves, vented their pain by incessant roarings. Such load and lamentable cries were to be heard as we walked along the streeets that would pierce the very heart to think of."" A modern fictional story of the plague, Year of Wonders, by Geraldine Brooks, was published in 2001.

Reference

- Bell, Walter George. "The Great Plague in London in 1665." London: John Lane, The Bodley Head, 1924.
- [http://www.gutenberg.org/etext/17221 History of the Plague in England by Daniel Defoe]

1665

Events

- March 4 - Start of the Second Anglo-Dutch War.
- March 6 - Philosophical Transactions of the Royal Society begins publication.
- March 16 - Bucharest allows Jews to settle in the city in exchange of annual tax of 16 guilders.
- June 3 - The Duke of York defeats the Dutch Fleet off the coast of Lowestoft.
- June 15 - Jean-Baptiste Denis makes the first blood transfusion from lamb to human.
- June 12 - England installs a municipal government in New York City. This was the former Dutch settlement of New Amsterdam.
- July 7 - King Charles II of England leaves London with his entourage, fleeing the Great Plague. He moves his court to Salisbury, then Exeter
- October 5 - The University of Kiel is founded.
- November 7 - The London Gazette, the oldest surviving journal, is first published.
- Charles II of Spain becomes King.
- London has its last severe outbreak of the Bubonic plague, possibly introduced by Dutch prisoners of war. Two-thirds of Londoners leave the city, but over 68,000 die. (See the Great Plague.)
- Rumours abound that syphilis wards off the Plague, causing many Londoners to frequent the brothels.
- Battle of Ambuila: Portuguese forces defeat and kill king Garcia II of Kongo, ending native rule of that kingdom.
- Molière publishes L'Amour médecin.
- John Bunyan publishes The Resurrection, Alexendre Le Grand, and The Indian Emperor.
- Approximate date of the discovery of the Great Red Spot.

Births

- February 6 - Queen Anne of Great Britain (d. 1714)
- February 12 - Rudolf Jakob Camerarius, German botanist and physician (d. 1721)
- March 4 - Philip Christoph von Königsmarck, Swedish soldier
- April 19 - Jacques Lelong, French bibliographer (d. 1721)
- April 29 - James Butler, 2nd Duke of Ormonde, Irish statesman and soldier (d. 1745)
- June 4 - Zacharie Robutel de La Noue, Canadian soldier (d. 1733)
- July 2 - Samuel Penhallow, English-born American colonist and historian (d. 1726)
- August 21 - Giacomo F. Maraldi, French-Italian astronomer (d. 1729)
- August 27 - John Hervey, 1st Earl of Bristol, English politician (d. 1751)
- December 25 - Lady Grizel Baillie, Scottish songwriter (d. 1746)
- December 28 - George FitzRoy, 1st Duke of Northumberland, English general (d. 1716) See also :Category:1665 births.

Deaths

- January 12 - Pierre de Fermat, French mathematician (b. 1601)
- January 31 - Johannes Clauberg, German theologian and philosopher (b. 1622)
- June 13 - Egbert Bartholomeusz Kortenaer, Dutch admiral (b. 1604)
- June 25 - Sigismund Francis of Austria, regent of Tyrol and Further Austria (b. 1630)
- July 11 - Kenelm Digby, English privateer (b. 1603)
- July 18 - Stefan Czarniecki, Polish general (b. 1599)
- September 12 - Jean Bolland, Flemish Jesuit writer (b. 1596)
- September 17 - King Philip IV of Spain (b. 1605)
- September 25 - Maria Anna of Austria (b. 1610)
- November 17 - John Earle, English bishop
- November 19 - Nicolas Poussin, French painter
- December 2 - Catherine de Vivonne, marquise de Rambouillet, French socialite (b. 1588)
- December 10 - Tarquinio Merula, Italian composer See also :Category:1665 deaths. Category:1665 ko:1665년

Disease

A disease is any abnormal condition of the body or mind that causes discomfort, dysfunction, or distress to the person affected or those in contact with the person. Sometimes the term is used broadly to include injuries, disabilities, syndromes, symptoms, deviant behaviors, and atypical variations of structure and function, while in other contexts these may be considered distinguishable categories. Pathology is the study of diseases. The subject of systematic classification of diseases is referred to as nosology. The broader body of knowledge about diseases and their treatments is medicine.

Syndromes, illness and disease

Medical usage sometimes distinguishes a disease, which has a known specific cause or causes (called its etiology), from a syndrome, which is a collection of signs or symptoms that occur together. However, many conditions have been identified, yet continue to be referred to as "syndromes". Furthermore, numerous conditions of unknown etiology are referred to as "diseases" in many contexts. Illness, although often used to mean disease, can also refer to a person's perception of their health, regardless of whether they in fact have a disease. A person without any disease may feel unhealthy and believe he has an illness. Another person may feel healthy and believe he does not have an illness even though he may have a disease such as dangerously high blood pressure which may lead to a fatal heart attack or stroke.

Transmission of disease

Some diseases, such as influenza, are contagious or infectious, and can be transmitted by any of a variety of mechanisms, including droplets from coughs and sneezes, by bites of insects or other vectors, from contaminated water or food, etc. Other diseases, such as cancer and heart disease are not considered to be due to infection, although micro-organisms may play a role.

Social significance of disease

The identification of a condition as a disease, rather than as simply a variation of human structure or function, can have significant social or economic implications. The controversial recognitions as diseases of post-traumatic stress disorder, also known as "shell shock"; repetitive motion injury or repetitive stress injury (RSI); and Gulf War syndrome has had a number of positive and negative effects on the financial and other responsibilities of governments, corporations and institutions towards individuals, as well as on the individuals themselves. The social implication of viewing aging as a disease could be profound, though this classification is not yet widespread. A condition may be considered to be a disease in some cultures or eras but not in others. Oppositional-defiant disorder, attention-deficit hyperactivity disorder, and, increasingly, obesity are conditions considered to be diseases in the United States and Canada today, but were not so-considered decades ago and are not so-considered in some other countries. Conversely, the number of people in the West who consider homosexuality to be a disease became widespread in the 20th century but has been decreasing in the last two decades. To consider a condition to be a disease can sometimes involve a negative social value judgement. Lepers were a group of afflicted individuals who were historically shunned and the term "leper" still evokes social stigma. Fear of disease can still be a widespread social phenomena, though not all diseases evoke extreme social stigma.

Other uses of the term

In biology, disease refers to any abnormal condition of an organism that impairs function. The term disease is often used metaphorically for disordered, dysfunctional, or distressing conditions of other things, as in disease of society.

External links

- [http://www.nlm.nih.gov/medlineplus/healthtopics.html Health Topics], MedlinePlus descriptions of most diseases, with access to current research articles.
- [http://www.cdc.gov/health/default.htm Center for Disease Control Health Topics A-Z], fact sheets about many common diseases
- [http://rarediseases.about.com/ Rare/Orphan Diseases]
- [http://www.national-health.org/rarediseases/ National Organization for Rare Disorders] Extensive, useful information on rare diseases.
- [http://www.merck.com/pubs/mmanual/sections.htm The Merck Manual], detailed description of most diseases, freely searchable online. Category:Diseases Category:Medical terms als:Krankheit zh-min-nan:Pīⁿ ms:Penyakit ja:病気 simple:Disease th:โรค

Britain

:This article deals with the history of the word Britain. For clarification of terminology and an overview of articles about Britain and Ireland see British Isles (terminology). The word Britain is an informal term used to refer to
- the island of Great Britain which consists of the nations of England, Scotland and Wales.
- the United Kingdom of Great Britain and Northern Ireland or UK,
- sometimes the Roman province called "Britain" or "Britannia" The word British generally means belonging to or associated with Britain in one of the first two senses above (i.e. the United Kingdom or the island of Great Britain). However, the term has a range of related usages, as described in this article. Etymologically, these words are closely related to Brittany, the name of the western French peninsula, and its adjective Breton.

Earliest attested references

- Pretaniké; Pretanikai nesoi (Pretanic isles) - 325 BC
- Britannia - 55 BC (Julius Caesar, Roman invasion of Britain)
- Breten - 855 (Old English Chronicle, introduction)
- Brittisc - 855 (OED)
- Grate Briteigne - 1548 (OED)
- British isles - 1550 (in Latin; map of Sebastian Munster cited in British Isles article)

Etymology

The etymology of the name Britain is thought to derive from a Celtic word, Pritani, "painted people/men", a reference to the inhabitants of the islands' use of body-paint and tattoos. If this is true, there is an interesting parallel with the name Pict, connected with a Latin word of the same meaning. The modern Welsh name for Britain is Prydain. The Q-Celtic form was Cruithin, showing that the Common Celtic singular form was qr[ui]tanos. The root is presumably that of the modern Gaelic/Irish word cruth 'shape, form'. It has also been postulated that Britain may derive from the Celtic goddess Brigid; the form of the word, however, is against this postulation. In 325 BC the Greek explorer Pytheas of Massalia visited a group of islands which he called Pretaniké, the principal ones being Albionon (Albion) and Ierne (Erin). The records of this visit date from much more recent times, so there is room for these details to be disputed, but it does seem to attest pre-Roman use of the name by Celtic-speaking inhabitants of the islands - or the names used by the Phoenecians Pytheas went with. The Roman geographer Ptolemy called the larger island Megale Brettania (Great Britain), and the smaller island Micra Bretannia (Little Britain).

Britain and Brittany

The original reference seems to have been to the territory in which the Brythonic languages were spoken, which more or less coincided with the Roman province of Britannia, an area equivalent to modern England, Wales and southern Scotland. In the Early Middle Ages speakers of a Brythonic language which later evolved into Breton migrated from Cornwall to Armorica, Western France, possibly because of pressure from Saxon invasions. This is why different forms of the same name apply to insular Britain and continental Brittany. In French the similarity is even more obvious: Bretagne and Grande Bretagne. Geoffrey of Monmouth used the names Britannia minor to refer to the Armorican region and Britannia major for the island. The element great in the term Great Britain thus simply means large, to make the distinction from Brittany.

Historical evolution of the term Britain

The kingdoms established on the island of Great Britain were perceived to be dominant over the whole archipelago, which thus came to be known as the British Isles. During the reign of Queen Elizabeth I of England, the queen's astrologer and alchemist, John Dee, wrote mystical volumes predicting a British Empire and using the terms Great Britain and Britannia. After Elizabeth's death in 1603 the kingdoms shared one King, James VI of Scotland and I of England. On 20 October 1604 he proclaimed himself "King of Great Brittaine" (thus including Wales and also avoiding the cumbersome title "King of England and Scotland"). This title was eventually adopted formally in 1707 when the Kingdom of Great Britain was formed. Politically, then, British has been used to described someone or something from the United Kingdom, in its various forms, since 1707. Briton or Brit are also used colloquially in this form, though the use of Briton here is incorrect. Since its formation, the kingdom was enlarged in 1801 by the addition of the island of Ireland - already ruled by the British monarchy - to become the United Kingdom of Great Britain and Ireland, and was then reduced in 1922 by the independence of the Irish Free State, now the Republic of Ireland. The name of the kingdom changed accordingly, in 1927 becoming The United Kingdom of Great Britain and Northern Ireland. British was also used to describe members of nations that formed part of the British Empire. This use now, however, could be seen as justifying the colonial era, even if only applied historically.

Modern use of the term 'British'

The modern use of the term 'British' is as an adjective to describe someone or something from the United Kingdom. It is officially used as the term to describe the nationality of a citizen of the United Kingdom. Irish Nationalists may reject this term as offensive, as it is used to describe Irish people in Northern Ireland. Many people from England, Scotland and Wales also dislike the term, preferring to define themselves as natives of their own particular country. It is also frequently used to describe residents of the United Kingdom's current colonies. This may still offend some people, though since the British Overseas Territories Act 2002 all residents of the United Kingdom's remaining colonies have been eligible for British citizenship, making the term more apt. British occurs in the legal term British Islands . This was coined to describe all of the islands of the British Isles, exlcuding those that form part of the Republic of Ireland, when they act together as a political whole. Geographically, the term can be used in various ways:
- To describe someone from the island of Great Britain
- In the term British Isles, the traditional term for the entire archipelago of islands that lie off the north west coast of France, of which Great Britain and Ireland are the two biggest. Note that this is not intended to imply that all of these islands are part of the United Kingdom, for many of them are part of the Republic of Ireland. However, confusion caused by this term can lead to offense.
- The term has historically been used to describe someone or something from the British Isles. Due to the above mentioned potential for offense, this rarely happens today. For example the British Lions a rugby team which draws players from the United Kingdom and the Republic of Ireland has been renamed to the British and Irish Lions.
- Sometimes British applies to an area or territory currently or formerly governed by or a dependent territory of the United Kingdom, for example the British Virgin Islands, the British Indian Ocean Territory, or British Columbia which is now a province of Canada.

Brutus of Troy

In keeping with the mediaeval penchant for etymologising country names in terms of eponomous heroes, English historians of the late mediaeval and early modern periods charted the history of the nation from Brutus of Troy, supposedly a hero of the Trojan war who founded Britain just as Aeneaus' descendant Romulus founded Rome, Frankus France, and so forth. The life of Brutus, anglicised as Brute, was recorded in the literary tradition of the Prose Brute. This was long accepted as the etymology of Britain.

Sources and further reading

- A History of Britain: At the Edge of the World, 3000 BC - 1603 AD by Simon Schama, BBC/Miramax, 2000 ISBN 0786866756
- A History of Britain, Volume 2: The Wars of the British 1603-1776 by Simon Schama, BBC/Miramax, 2001 ISBN 0786866756
- A History of Britain - The Complete Collection on DVD by Simon Schama, BBC 2002
- The Isles, A History by Norman Davies, Oxford University Press, 1999, ISBN 0195134427
- Shortened History of England by G. M. Trevelyan Penguin Books ISBN 0140233237
- Origins: A Short Etymological Dictionary of Modern English by Eric Partridge, Routledge & Kegan Paul, London, 1966

External links

- [http://www.british-history.ac.uk/ British History Online] Category:British Isles Category:History of Britain Category:Europe simple:Britain

London

London is the capital city of the United Kingdom and of England. As Europe's richest city, London produces 17% of the UK's GDP, and is one of the world's major business and financial centres. The capital of the former global empire, London is a leader in culture, communications, politics, finance, entertainment and the arts and has considerable influence worldwide. arts]] arts] London is the most populous city in the European Union, with an estimated population on 1 January 2005 of 7,500,000 and a metropolitan area population of between 12 and 14 million. London's population includes an extremely diverse range of peoples, cultures, and religions, making it one of the most cosmopolitan, vibrant and energetic cities on earth. A resident of London is referred to as a Londoner. Over 300 languages are spoken in London, making it the most linguistically diverse city in the world. Initially it was a Roman city and known as Londinium and then as Lunnainn, Llundain and Londain in the Scottish, Welsh and Irish languages respectively. London is known by these names in other languages. London is the home of many global organisations, institutions and companies, and as such retains its leading role in global affairs. A city where cutting-edge meets tradition, London is a major tourist destination and transport hub. It has a great number of important buildings and iconic landmarks, including world-famous museums, theatres, concert halls, galleries, airports, sports stadia and palaces. London is one of the world's major global cities (along with New York City, Tokyo and Paris).

Defining London

Today, "London" usually refers to the conurbation known as Greater London, which is divided into thirty-two London Boroughs and the City of London and forms the London region of England. Historically, "London" referred to the square mile of the City of London at the conurbation's heart, from which the city grew. Between 1889 and 1965 it referred to the former County of London which covered the area now known as Inner London. There are other definitions of "London" which cover varying areas, such as the London postal district; the area covered by the telephone area code 020; the area accessible by public transport using a Transport for London Travelcard; the area delimited by the M25 orbital motorway; the Metropolitan Police district; and the London commuter belt. The coordinates of the centre of London (traditionally considered to be Charing Cross, near the junction of Trafalgar Square, the Strand, Whitehall and the Mall) are approximately . The Romans marked the centre of Londinium with the London Stone in the City.

Geography and climate

London Stone, with Green Park and St. James's Park to its right]] Greater London covers an area of 609 square miles (1,579 km²). London is a port on the Thames, a navigable river. The river has had a major influence on the development of the city. London was founded on the north bank of the Thames and there was only a single bridge, London Bridge, for many centuries. As a result, the main focus of the city was on the north side of the Thames. When more bridges were built in the 18th century, the city expanded in all directions as the mostly flat or gently rolling countryside around the Thames floodplain presented no obstacle to growth. There are some hills in London, examples being Parliament Hill and Primrose Hill, but these provided fine prospects of the city centre without significantly affecting the directions of the spread of the city and London is therefore roughly circular. The Thames was once a much broader, shallower river than it is today. It has been extensively embanked, and many of its London tributaries now flow underground. The Thames is a tidal river, and London is vulnerable to flooding. The threat has increased over time due to a slow but continuous rise in high water level and the slow 'tilting' of Britain (up in the north and down in the south) caused by post-glacial rebound. The Thames Barrier was constructed across the Thames at Woolwich in the 1970s to deal with this threat, but in early-2005 it was suggested that a ten-mile-long barrier further downstream might be required to deal with the flood risk in the future [http://news.bbc.co.uk/1/hi/england/london/4162905.stm]. London has a temperate climate, with warm but seldom hot summers, cool but rarely severe winters, and regular but generally light precipitation throughout the year. Summer temperatures rarely rise much above 33°C (91°F), though higher temperatures have become more common recently. The highest temperature ever recorded in London was 38.1°C (100.6°F), measured at Kew Gardens during the European Heat Wave of 2003. Heavy snowfalls are almost unknown. In recent winters, snow has rarely settled to more than an inch (25 mm). London's average annual precipitation of less than 24 inches (600 mm) is lower than that of Rome or Sydney. London's large built-up area creates a microclimate, with heat stored by the city's buildings: sometimes temperatures are 5°C (9°F) warmer in the city than in the surrounding areas.

History

microclimate bombings of London]] The name London is commonly thought to have come from the Latin name Londinium, as London was founded by the Romans during their reign over the land, around 43AD – although there is some slight evidence of pre-Roman settlement. The [http://www.bbc.co.uk/history/timelines/england/rom_roman_invasion.shtml BBC History website], however, claims that the name Londinium is actually "Celtic, not Latin, and may originally have referred to a previous farmstead on the site"; the root is 'Lond' meaning 'wild' (i.e. overgrown or forested) place. This fortified Roman settlement was the capital of the province of Britannia. According to findings displayed in London Museum, the initial language of London was Latin with much Greek spoken due to the presence of Greek speaking Roman soldiers and businessmen. Another suggestion for where the name of the city comes from could be that of the mythical leader, King Lud. It was said that Lud laid out the first set of roads in the city. His statue can be seen hidden at the church of St Dunstan's In The West, Fleet Street. Around AD 61 the Iceni tribe of Celts lead by Queen Boudica stormed London and took the city from the Romans. The Celts burnt the relatively new Roman town to the ground, and archaeological digs have revealed a layer of red ash beneath the City of London, which is believed to be the burnt remains of the old Roman town. After the fall of the Roman Empire, Londinium was abandoned and a Saxon town named Lundenwic was established approximately one mile to the west in what is now Aldwych, in the 7th century. The old Roman city was then reoccupied during the late-9th or early-10th century. Westminster was once a distinct town, and has been the seat of the English royal court and government since the mediæval era. Eventually, Westminster and London grew together and formed the basis of London, becoming England's largest – though not capital – city (Winchester was the capital city of England until the 12th century). London has grown steadily over centuries, surrounding and making suburbs of neighbouring villages and towns, farmland, countryside, meadows and woodlands, spreading in every direction. From the 16th to the early-20th century, London flourished as the capital of the British Empire. In 1666, the Great Fire of London swept through and destroyed a large part of the City of London. Rebuilding took over 10 years, but London's growth accelerated in the 18th century, and, by the early-19th century, it was the largest city in the world. London's local government system struggled to cope with this rapid growth, especially in providing the city with adequate infrastructure. In 1855 the Metropolitan Board of Works was created to provide London with infrastructure to cope with its growth. In 1889 the MBW was abolished, and the County of London was created which was administered by the London County Council, the first elected London-wide administrative body. Probably the most significant changes to London in the last 100 years were as a result of the Blitz and other bombing by the German Luftwaffe that took place during World War II. The bombing killed over 30,000 Londoners and flattened large tracts of housing and other buildings across London. The rebuilding during the 1950s, 1960s and 1970s was characterised by a wide range of architectural styles and has resulted in a lack of unity in architecture that has become part of London's character. Until their 1997 ceasefire, London was regularly a target for IRA bombers seeking to pressurise the British government into negotiations with Sinn Féin on Northern Ireland. On 7 July 2005, there was a series of coordinated bomb attacks by Islamic extremist suicide bombers on three underground stations and a bus. The explosions came less than 24 hours after London was awarded the 2012 Summer Olympics and as the G-8 summit was underway in Gleneagles, Scotland. A series of explosions also took place on 21 July 2005; however, in the latter incident, there were no fatalities.

Modern London

2005 Today Greater London comprises the City of London and the 32 London boroughs (including the City of Westminster). 12 of these boroughs are defined as Inner London, the remaining 20 defined as Outer London. The dominant centre of activity in London is the City of Westminster (including the West End) which is the main cultural, entertainment and shopping district, the location of most of London's major corporate headquarters outside of the financial services sector, and the centre of the UK's national government. The City of London (also known as the "Square Mile") is at the centre of international finance, and is Europe’s main business centre. The headquarters of more than 100 of Europe’s 500 largest companies are all in London. The London foreign exchange market is the largest in the world, with an average daily turnover of $504 billion, more than the New York and Tokyo exchanges combined. While very busy during the working week, most parts of the City tend to be quiet at weekends, since it is primarily a non-residential area. London is one of the most visited cities on earth. Tourist attractions are located mainly in Central London, comprising the historic City of London; the West End with its many cinemas, bars, clubs, theatres, shops and restaurants; the City of Westminster with Westminster Abbey, the Royal palaces of Buckingham Palace, Clarence House etc., the Royal Borough of Kensington and Chelsea with its museums (the Science Museum, Natural History Museum, and Victoria and Albert Museum) and Hyde Park. Other important tourist attractions include St Paul's Cathedral, the National Gallery; the South Bank and Bankside areas of Southwark with the Globe Theatre and the Tate Modern; London Bridge, Tower Bridge, the Tower of London, and the Tate Britain on the Embankment; and the British Museum in Bloomsbury. There are many other places of interest across the city.

Culture

:Main article: Culture of London. London is an international centre of culture in all its forms - music, theatre, arts, museums, festivals and much more.

London Districts

See also: Inner London, Outer London.

Central London

City of London

Outer London]] The City of London is the principal financial district of the United Kingdom, and is one of the most important in the world. It is governed by the Corporation of London, an ancient body headed by the Lord Mayor of London. The City also has its own police force, the City of London police. Once dominated by the dome of St Paul's Cathedral, it is now home to many skyscrapers, including Tower 42 (formerly, and popularly still, known as the NatWest Tower) and 30 St Mary Axe (popularly known as the "Gherkin", built in 2003). The City has only a small (c. 7,000) resident population, but a daytime working population of more than 300,000. Its primacy as the chief financial district has been directly challenged in recent years by Canary Wharf in East London.

The West End

Canary Wharf.]] The West End is the most popular shopping and entertainment district in London. Trafalgar Square is the most prominent landmark. Oxford Street is one of the best-known shopping streets in the world. Running from Charing Cross Road in the east to Marble Arch in the west, via Oxford Circus where it crosses Regent Street, it is home to many large department stores and shops (Selfridges, John Lewis, Marks and Spencer). Tottenham Court Road runs north from the eastern end of Oxford Street towards the north of the city centre, and is best known for its plethora of hi-fi, computer and electronics stores. West of the City, Covent Garden is home to the Avenue of Stars, London's version of Hollywood's Walk of Fame. South of Oxford Street's eastern end is Soho, a network of small streets crowded with restaurants, pubs, clubs, smaller shops and boutiques, and theatres and cinemas, as well as media companies and film, advertising and post-production companies. Soho is also well known for its very lively club and bar scene, the notorious sex industry and as the major "gay quarter" of the city. Piccadilly is an elegant thoroughfare running from Piccadilly Circus in the east to Hyde Park Corner in the west. It is adjacent to Mayfair, and Green Park. Regent Street and Bond Street are important thoroughfares.

East London

East London saw much of London's early industrial development and much of it now is being extensively redeveloped as part of the Thames Gateway. It was also key to London's successful bid to host the 2012 Olympics, and is now scheduled to undergo extensive regeneration in the run-up to the games. This is the second time in modern history that East London has seen large-scale rebuilding: it took the full force of the Blitz in World War Two, with post-war reconstruction leaving a legacy of bleak housing estates and tower blocks in several areas.

The East End

tower block The East End of London is closest to the original Port of London, and tended for that reason to be the area of the city where immigrants arriving into the port would settle first. Successive waves of immigrants include the French, the Huguenots, Belgians, Jews, Gujaratis, Pakistanis, Bangladeshis and many other groups. The East End extends from the eastern side of the City of London and includes areas such as Whitechapel, Mile End, Bethnal Green, Hackney, Bow, Millwall and Poplar. The area has many places of interest including many of London's markets, (for example Columbia Road Flower Market, Spitalfields Market, Brick Lane Market, Petticoat Lane Market), and several museums, including the Geffrye Museum and the Museum of Childhood in Bethnal Green.

Docklands

Bethnal Green]] The London Docklands, on the Isle of Dogs along the Thames in the East End, has developed enormously since the early-1980s. For a period in the early-1980s, many warehouse buildings in Wapping had been occupied and used as artists studios and low-cost loft living spaces. This inevitably drew the attention of property developers who gradually (and then not so gradually) moved in to take over. The London Docklands Development Corporation (LDDC) was set up in 1981 to accelerate the process, and the first phases of major development started to reshape the area, culminating in Canary Wharf, whose best-known feature is the 1 Canada Square office tower (which is often incorrectly called "Canary Wharf"), which has been the UK's tallest skyscraper since 1991. A massive-scale development within the last three or four years has added a great many more skyscrapers, and many large businesses (investment banks, law firms, etc.) have moved in. A new headquarters for HSBC and Barclays as well as the European headquarters of Citigroup, have now been completed, and are in use. Attracted by this growth, restaurants, bars and nightclubs have opened, there are three interconnected shopping malls beneath the Canary Wharf structure, and a cinema complex has opened in the area. The Docklands Light Railway (DLR) serves the area, connecting to the London Underground at Bank, Shadwell, Canning Town and Stratford stations. There has also been a great deal of gentrification and residential development in the area: North of the Thames around Limehouse Basin and toward Wapping, as well as south of the Thames in Rotherhithe where former wharfs and the old docks have been converted into high-priced loft apartments for a community of bankers, software developers and others working in the financial service industries in and around Docklands. Further east in the London Borough of Newham are London City Airport and the ExCeL Exhibition Centre.

West London

West London includes many of the traditionally fashionable and expensive residential areas such as Notting Hill, made better known in 1999 by a film of the same name starring Hugh Grant and Julia Roberts. Within the district is the famous antique market at Portobello Road. Kensington and Chelsea are the most expensive places to live in the country. The area is also famous for the Kings Road, a distinguished and attractive shopping street and thoroughfare. Further to the west, at White City, near Shepherd's Bush, is the principal operating centre for the BBC, while in the extreme west, in the London Borough of Hillingdon, lies Heathrow Airport. Considered more south-west than West London on account of its being the only London borough to straddle the River Thames, Richmond upon Thames includes the attractive riverside districts of Richmond and Twickenham. This corner of London is home to Richmond Park, London's largest, and Twickenham, the home of English rugby union.

North London

North London includes suburbs such as Hampstead and Highgate, which retain a village atmosphere. North London is more hilly than the south, and many of the hills give excellent views across the city. Large parks include Hampstead Heath, which includes Parliament Hill, noted for its fine views over the city, and the Hampstead bathing ponds; and Alexandra Park, site of Alexandra Palace. Many areas have significant minority populations including Stamford Hill, home to a significant community of Orthodox Jews, the Green Lanes area of Harringay and the Finsbury Park area have large Turkish and Greek communities. Islington is considered one of the more affluent areas in London, due to large scale gentrification, although it is in fact one of the most deprived boroughs in the country; it is also home to Arsenal football club. North London's other world-famous football team, Tottenham Hotspur, play in nearby Tottenham.

South London

South London contains such diverse districts as Wimbledon (famous as the home of the major tennis Wimbledon Championships), Bermondsey, and Dulwich. Redevelopment of the Elephant and Castle, a road intersection and district close to the centre, is due to start in 2006. Greenwich is on the banks of the Thames where the river broadens into a wide meandering reach of muddy water. It is an historic neighbourhood and boasts a fine park and the Royal Greenwich Observatory. It is also has a popular market. Brixton, Camberwell and Peckham are home to many families (and their descendants) who immigrated to London from the West Indies during the 1950s, 1960s and 1970s, sometimes known as Afro-Caribbeans.

Demographics

Afro-Caribbeans London had about 860,000 people in 1801 (in comparison, Paris had about 670,000 in 1802), and the population of Edo (modern-day Tokyo, Japan), at the time the largest city in the world, has been estimated at 1 million to 1.25 million people. London was the most populous city in the world from 1825 until 1925, when it was overtaken by New York. Residents of London are known as Londoners. The city and the 32 boroughs (some 1,579 km² or 610 square miles) had an estimated 7,421,228 inhabitants in 2004, making London the most populous city in Europe alongside Moscow. Subsequent reviews suggested that the returns were understated, and that the population on Census Day was closer to 7.29 million. The official estimate of London's population in mid-2003 is 7,387,900 [http://www.statistics.gov.uk/statbase/Expodata/Spreadsheets/D8561.xls] In the 2001 census, 76% of these seven million people classed their ethnic group as white (classified as British White, Irish White or "Other White" in the 2001 census), 10% as Indian, Bangladeshi or Pakistani, 5% as black African, 5% as black Caribbean, 3% as mixed race and 1% as Chinese. The largest religious groupings are Christian (58.2%) and No Religion (15.8%). 21.8% of inhabitants were born outside the European Union. The Irish are the largest foreign-born group in London (numbering approximately 200,000). European Union] Unlike many other countries, the UK does not provide national metropolitan area population figures based on commuter percentages and economic influence. This is left up to each individual city to define. This has created much confusion when comparing London's true metropolitan area region with others around the world. It is helped even less by confusion of the term "Greater London" with the political entity of the City of London, which is often confused with the metropolitan area. Without a specific national reference to London's metropolitan area, many different sources provide alternate definitions. One widely regarded definition describes the London metropolitan area (6,267 square miles, 16,043 km²) with a population of 13,945,000 — larger than the combined populations of Scotland, Wales and Northern Ireland. (External references: [http://www.demographia.com/dm-lonarea.htm], [http://www.lbwf.gov.uk/demography/census/london/london_boroughs_census2001.pdf]) If this definition is followed, then London is the largest metropolitan area of Europe, along with Moscow (whose metropolitan area has somewhere around 14 million people), and above Paris (11.5 million people in the metropolitan area in 2004). In 2004, the Greater London Authority defined a metropolitan region centred on London with a population of 18 million. This region extends to cover the commuter belt, and much of South East England and East of England, for example including the cities of Brighton and Oxford. (External references:[http://www.london.gov.uk/mayor/strategies/sds/london_plan/lon_plan_all.pdf],[http://www.london.gov.uk/mayor/strategies/sds/london_plan/lon_plan_1.pdf],[http://www.london.gov.uk/mayor/strategies/sds/draft_london_plan/dlp_ch1.pdf])

Government

Greater London Authority meets here]] Greater London is divided into the 32 London boroughs and the City of London. The boroughs are the most important unit of local government in London, and are responsible for running most local services in their respective areas. The City of London is run not by a conventional local authority, but by the historical Corporation of London. The Greater London Authority (GLA) is the London-wide body responsible for co-ordinating the boroughs, strategic planning, and running some London-wide services such as policing, the fire service and transport. The GLA consists of the Mayor of London and the London Assembly. The mayor is elected by the Supplementary Vote system while the assembly is elected by the Additional Member System. The incumbent Mayor of London, Ken Livingstone, was elected as an independent candidate in the 2000 election. Despite opposition from all the main political parties and the press, his popularity with Londoners has remained high. Livingstone was expelled from the Labour Party when he opposed the official Labour candidate Frank Dobson in the 2000 Mayoral election. Readmitted by that party in 2004, he was re-elected as Mayor as an official Labour candidate in the election later that year. The GLA was created in 2000 as a replacement body for the former Greater London Council (GLC) which was created in 1965 and abolished in 1986 after political disputes between the GLC (then led by Ken Livingstone) and the Conservative government of Margaret Thatcher. Previous London wide administrative bodies were the Metropolitan Board of Works (MBW) from 1855 to 1889; the London County Council (LCC) from 1889 to 1965; and the Greater London Council (GLC) from 1965 to 1986. When the GLC was abolished, most of its functions were devolved to the London boroughs, while others were taken over by joint-boards or other unelected bodies. The boroughs thus enjoyed "unitary status" and a degree of autonomy when the GLC was abolished, and although losing some powers which have been repatriated to the GLA they still retain many areas they did not control under the GLC. London is represented in Parliament by 74 MPs. For a list of London constituencies see List of Parliamentary constituencies in Greater London. The territorial police force for the 32 London boroughs is the Metropolitan Police Service, more commonly referred to as the Metropolitan Police, or simply "the Met". The City of London has its own police force, the City of London Police. Health services in London are managed by the national government via the National Health Service (NHS). Greater London is divided into five Strategic Health Authorities [http://www.nhs.uk/england/authoritiestrusts/sha/MapSearch.aspx?rg=Y21].

Transport and infrastructure

For main article see Transport and infrastructure in London Transport and infrastructure in London Transport is one of the four areas of policy administered by the Mayor of London, but the mayor's financial control is limited. The executive agency which runs London's transport system is Transport for London (TfL). The public transport network is one of the most extensive in the world, but faces congestion and reliability issues. The network is one of the most complex transit systems in the world with just over 1 billion journeys used every year on the underground alone. London is most famous for its AEC Routemaster buses which have been in service in the capital since 1956. Routemasters will be phased out of service from TfL's main bus routes, with the last routemaster service being operated on the 9 December 2005 on Route 159. Two 'heritage' routes are planned for service to maintain Routemasters on London's streets. 2005]] The networks for transport in London include: Underground (commonly known as the tube); Bus; River Services; Docklands Light Railway (DLR); Croydon Tramlink; National Rail; Thameslink. As of mid-2005, in preparation for the 2012 London Olympic Games a total of £7 billion ($12 billion) will be spent on refurbishment and expansion of city links, mainly on the London Underground. Although the main reason for this is because of the increased traffic flow that will be caused by the 2012 Olympics, the work would still be completed if London had not won the games. By 2013 a new service called Crossrail is due to be opened. Also in planning is the Cross River Tram (CRT). It will depart in the south suburbs, cross the River Thames, through to the City of London (the financial district), and continue its journey to the northern suburbs. It is speculated that it will be the world's longest tram. The main Olympic arenas will be sited close to Stratford International station, which is currently being constructed as part of the Channel Tunnel Rail Link. The new high-speed line, due to open in 2007, will be used by the regular 'Olympic Javelin' service with a journey time of 7 minutes between Stratford and St Pancras. This service was a key part of the Olympic bid and will provide access from northern areas of the UK via King's Cross and Euston.
Education
Main Article: Education in London London is home to a diverse number of universities, colleges and schools, and is a leading centre of research and development. This includes prominemnt universities such as Imperial College, London and the London School of Economics

Media

The British media is concentrated in London and is sometimes accused of having a "London bias". All the major television networks are headquartered in London including the BBC, which remains one of the world's most influential media organisations. Partly to counter complaints about London bias, the BBC announced in June 2004 that some departments (BBC Sport, CBBC, Cbeebies, BBC Three and BBC Radio Five Live) are to be relocated to Manchester. Other major networks include ITV, Channel 4, Five and BSkyB - all based in London. Like the BBC, these produce some programmes elsewhere in the UK, but London is their main production centre. There is a huge choice of radio stations available in London. Local city-wide stations include music-based stations such as Capital FM, Heart 106.2 and Kiss 100 and popular news/talk stations include BBC London, LBC 97.3 and LBC News 1152. The London newspaper market is dominated by national newspapers, all of which are edited in London. Until the 1970s, most of the national newspapers were concentrated in Fleet Street, but in the 1980s they relocated to new premises with automated printing works. Most of these are in East London, most famously the News International plant at Wapping. The move was resisted strongly by the printing trade union SOGAT 82, and strike action at Wapping in 1986 led to violent skirmishes. The last major news agency in Fleet Street, Reuters, moved to Canary Wharf in 2005, but Fleet Street is still commonly used as a collective term for the national press. Regional Editions of most national newspapers are available, including editions for northern England, Scotland and Wales. London has three daily newspaper titles - the popular Evening Standard, plus two free titles, Metro and Standard Lite (published by the Evening Standard) which are distributed every morning at London tube and railway stations. The independent weekly listings guide Time Out Magazine has been providing concert, film, theatre and arts information since 1968. London is at the centre of British film and television production industries, with major studio facilities on the western fringes of the conurbation and a large post-production industry centred in Soho. London is one of the two leading centres of English-language publishing alongside New York. Globally important media companies based in London range from publishing group Pearson, to the information agency Reuters, to the world's number two advertising business WPP Group. There are a vast number of local newspapers in the London area, often covering a small section of the vast city.

Religion

local newspapers When Pope Gregory the Great sent St. Augustine to bring England into the Catholic fold in 597, it was intended that the envoy should become "Archbishop of London", as the city was remembered as the capital of Roman Britain. In the event, the saint received his most hospitable reception in the Kingdom of Kent, and the archiepiscopal see was founded at Canterbury. Nonetheless London has been at the centre of England's religious life for much of its history, and each Archbishop of Canterbury has traditionally spent much of his time in London, where he has an official residence at Lambeth Palace. London's two Anglican bishops are the Bishop of London, whose see is London north of the Thames, and whose throne is in London's grandest church, the baroque St Paul's Cathedral (designed by Sir Christopher Wren), and the Bishop of Southwark, who tends to Anglicans south of the river. Important national and royal ceremonies are divided between St Paul's and Westminster Abbey, a gothic church on the scale of a cathedral. As in the rest of the UK, religious attendance in London is low, and the Church of England has borne the brunt of this decline. The Roman Catholic Archbishop of Westminster is generally regarded as the leader of the Catholic Church in England and Wales. Other traditional Protestant denominations whose headquarters are in London include the United Reformed Church and the Quakers. Many of London's immigrant groups have established denominations in the city, for example Greek Orthodoxy. In addition various evangelical churches exist. London is the most important centre of Islam in the United Kingdom. Two London boroughs contain the highest proportion of Muslims in the UK: Tower Hamlets and Newham. The London Central Mosque is a well-known landmark on the edge of Regent's Park, and there are many other mosques in the city. London also has the largest Hindu population outside of India. Southall, in West London is home to many Hindus. The Hindu temple at Neasden, Neasden Temple is the largest Hindu temple outside of India and a remarkable example of a modern building in a traditional style. Much of the enormously elaborate and intricate marble sculpture used in the building was carved in India. Over two-thirds of British Jews live in London, which ranks thirteenth in the world as a Jewish population centre [http://www.jafi.org.il/education/100/concepts/demography/demtables.html#10].

Sport

British Jews London hosts one of the world's largest mass-participation marathons, the London Marathon, and has hosted the Olympic Games in 1908 and 1948. In July 2005 London was chosen to host the Games in 2012. London will be the first city in the world to host the Summer Olympics three times. The most popular spectator sport in London is football, and London has several of England's leading football clubs. Historically the London clubs have not accumulated as many trophies as those from the North West of England, such as Liverpool and Manchester United, but at present Arsenal (founded at Woolwich Arsenal but moved to Highbury in 1913), and Chelsea (who play in Fulham) are regarded as two of the Premier League's "Big three" alongside Manchester United. In 2003-04 they became the first pair of London clubs to finish first and second in the top flight, with Arsenal winning. In 2004-05 they did so again, this time with Chelsea winning. London clubs are able to charge higher ticket prices than clubs in other parts of the country (particularly for corporate facilities), and this has swung English football's balance of power towards London. Before Chelsea's recent rise in fortunes the two highest profile London clubs were Arsenal and their long-standing North London rivals Tottenham Hotspur, both of whom were considered to be members of English football's "Big five" for most of the post-war period. In 2005-06 there are six London clubs in the Premier League: Arsenal, Tottenham and Chelsea, plus Charlton Athletic, Fulham and West Ham United. There are also five London clubs in the fully professional Football League (the level below the Premiership), namely Brentford, Crystal Palace (who play in South Norwood), Leyton Orient, Millwall and Queens Park Rangers (QPR)—all of whom have previously played in the top division. In a controversial move, Wimbledon left London in 2003 to play in Milton Keynes, Buckinghamshire, changing their name to Milton Keynes Dons; the newly formed AFC Wimbledon inherited most of their support, despite playing at a much lower level in the football pyramid. There are also numerous London clubs playing outside the top four divisions of English football, one or two of which are fully professional and many of which are part-time professional. Wembley Stadium in north-west London is the national football stadium, traditionally the home of the FA Cup Final as well as England national side's home matches. Currently, Wembley is being completely rebuilt, so Cardiff's Millennium Stadium has been the venue for recent FA Cup finals, while England play at various venues around the country. Wembley was one of the venues for the , and the 1996 European Championship, and hosted the final of both tournaments. It also was the venue for the European Cup final in 1968, 1978 and 1992. As well as football matches, Wembley has hosted many other sporting events, including the Rugby League Challenge Cup final. Rugby Union is also well established in London, especially in the middle-class suburbs to the north and west of the city. The (after J Columbina). The beak is a primitive gas mask, stuffed with substances (such as spices and herbs) thought to ward off the plague.]] Bubonic plague is an infectious disease that is believed to have caused several epidemics or pandemics throughout history. The disease is caused by the bacterium Yersinia pestis. Bubonic plague is the most common form of plague, and is characterized by swollen, tender, inflamed lymph glands (called buboes); other forms are Septicemic plague, which occurs when plague bacteria multiply in the blood, and Pneumonic plague, which occurs when the lungs are infected.

Infection/transportation

Bubonic plague is primarily a disease of rodents, particularly marmots (in which the most virulent strains of plague are primarily found), but also black rats, prairie dogs, chipmunks, squirrels and other similar large rodents. Human infection most often occurs when a person is bitten by a rat flea (Xenopsylla cheopsis) that has fed on an infected rodent. The bacillus multiplies in the stomach of the flea, blocking it. When the flea next bites a mammal, blood consumed by the flea is regurgitated along with the bacillus into the bloodstream of the bitten animal. Any serious outbreak of plague is started by other disease outbreaks in the rodent population. During these outbreaks, infected fleas that have lost their normal hosts seek other sources of blood. In 1894, bacteriologists Alexandre Yersin and Shibasaburo Kitasato independently isolated the responsible bacterium and Yersin further determined that rodents were the likely common mode of transmission. The disease is caused by the bacterium Yersinia pestis.

Symptoms and treatment

The disease becomes evident 2–7 days after infection. Initial symptoms are chills, fever, headaches, and the formation of buboes. The buboes are formed by the infection of the lymph nodes, which swell and become prominent. If unchecked, the bacteria infects the bloodstream (septicemic plague), and can progress to the lungs (pneumonic plague). In septicemic plague there is bleeding into the skin and other organs, which creates black patches on the skin. Untreated septicemic plague is universally fatal, but early treatment with antibiotics (usually streptomycin or gentamicin) is effective, reducing the mortality rate to around 15% (USA 1980s). People who die from this form of plague often die on the same day symptoms first appear. With pneumonic plague infecting lungs comes the possibility of person-to-person transmission through respiratory droplets. The incubation period for pneumonic plague is usually between two and four days, but can be as little as a few hours. The initial symptoms of headache, weakness, and coughing with hemoptysis are indistinguishable from other respiratory illnesses. Without diagnosis and treatment, the infection can be fatal in one to six days; mortality in untreated cases may be as high as 95%. The disease can be effectively treated with antibiotics.

Historical epidemics

The first Western literary account of a possible outbreak of plague is found in the book of Samuel V of the Hebrew Bible. In this account, the Philistines of Ashdod were struck with a plague for the crime of stealing the Ark of the Covenant from the Children of Israel. These events have been dated to approximately the second half of the eleventh century B.C. The word "hemorrhoids" is used in English translations to describe the sores that came upon the Philistines. The Hebrew, however, can be interpreted as "swelling in the secret parts". The account indicates that the Philistine city and its political territory were struck with a "ravaging of mice" and a plague, bringing death to a large segment of the population. In the second year of the Peloponnesian War (430 B.C.), Thucydides described the coming of an epidemic disease which began in Ethiopia, passed through Egypt and Libya, and then came to the Greek world. Athens was decimated by this plague, losing a possible third of its populace, including Pericles (Speilvogal, J, 1999, pp. 56). In spite of the loss in population, this did not affect the progress and outcome of the war. This epidemic has long been considered an outbreak of bubonic plague. However, from Thucydides' description, some modern scholars dispute the assignment of plague, feeling that smallpox or measles may be better candidates. In the first century AD, Rufus of Ephesus, a Greek anatomist, refers to an outbreak of plague in Libya, Egypt, and Syria. He records that Alexandrian doctors named Dioscorides and Posidonius described symptoms including acute fever, pain, agitation, and delirium. Buboes—large, hard, and non-suppurating—developed behind the knees, around the elbows, and "in the usual places." The death toll of those infected was very high. Rufus also wrote that similar buboes were reported by a Dionysius Curtus, who may have practiced medicine in Alexandria in the third century B.C. If this is correct, the eastern Mediterranean world may have been familiar with bubonic plague at that early date. (ref. Simpson, W.J., Patrick, A.) The last significant European outbreak of bubonic plague occurred in Russia in A.D. 1877–1889 in rural areas near the Ural Mountains and the Caspian Sea. This outbreak is sometimes seen as an extension of the Third Pandemic (see below). Efforts in hygiene and patient isolation reduced the spread of the disease, with approximately 420 deaths in the region. Significantly, the region of Vetlianka in this area is near a population of the "bobak", a type of small marmot considered a very dangerous plague reservoir.

Historical pandemics

Plague of Justinian

:For more complete information, see Plague of Justinian. :See also Climate changes of 535-536. The Plague of Justinian is the first known pandemic on record, and marks the first firmly recorded pattern of bubonic plague in A.D. 541–542. This outbreak is thought to have originated in Ethiopia or Egypt. The huge city of Constantinople imported massive amounts of grain, mostly from Egypt, to feed its citizens. The grain ships may have been the source of contagion for the city, with massive public granaries nurturing the rat and flea population. At its peak the plague was killing 5,000 people in Constantinople every day and ultimately destroyed perhaps 40 percent of the city's inhabitants. It went on to destroy up to a quarter of the human population of the eastern Mediterranean. In A.D. 588 a second major plague wave spread through the Mediterranean into what is now France. A maximum of 25 million dead is considered a reasonable estimate.

Black Death

:For more complete information, see Black Death. During the mid-14th century, the Black Death, a massive and deadly epidemic, swept through Eurasia, killing one-third of the population (according to some estimates) and changing the course of Asian and European history. The 200 million victims, throughout the many years of infection, constituted the largest death toll from any known epidemic. Many scientists and historians believe the Black Death was an incidence of bubonic plague. A strong presence of the more contagious pneumonic and septicemic varieties increased the pace of infection, spreading the disease deep into inland areas of the continents. Plague continued to strike parts of Europe throughout the 15th century, the 16th century and the 17th century with varying degrees of intensity and fatality. Researchers still do not agree on why large outbreaks of the infection have not returned to Europe; however, changes in hygiene habits and strong efforts within public health and sanitation probably had a significant impact on the rate of infection from the disease.

Third Pandemic

:For more complete information see Third Pandemic. The Third Pandemic began in China in 1855, spreading the bubonic plague to all inhabited continents, and ultimately killing more than 12 million people in India and China alone. Casualty patterns indicate that waves of this pandemic may have been from two different sources. The first was primarily bubonic and was carried around the world through ocean-going trade, transporting infected persons, rats, and cargos harboring fleas. The second, more virulent strain was primarily pneumonic in character, with a strong person-to-person contagion. This strain was largely confined to Manchuria and Mongolia. Researchers during the "Third Pandemic" identified plague vectors and the plague bacillus, leading in time to modern treatment methods.

Plague as a biological weapon

Plague has a long history as a biological weapon. Historical accounts from medieval Europe detail the use of infected animal carcasses, by Mongols, Turks and other groups, to contaminate enemy water supplies. Plague victims were also reported to have been tossed by catapult into cities under siege. During World War II, the Japanese Army developed weaponized plague based on the breeding and release of large numbers of fleas. During the Japanese occupation of Manchuria, Unit 731 deliberately infected civilians and prisoners of war with the plague bacillus. These subjects, called "logs", were then studied by dissection, some while still living and conscious. After World War II, both the United States and the Soviet Union developed means of weaponizing pneumonic plague. Experiments included various delivery methods, vacuum drying, sizing the bacillus, developing strains resistant to antibiotics, combining the bacillus with other diseases, such as diphtheria, and genetic engineering. Scientists who worked in USSR bio-weapons programs have stated that the Soviet effort was formidable and that large stocks of weaponized plague bacillus were produced. Information on many of the Soviet projects is largely unavailable. Aerosolized pneumonic plague remains the most significant threat.[http://www.vnh.org/BIOCASU/9.html][http://www.biohazardnews.net/agent_plague.shtml] USSR

Contemporary cases

The disease still exists in wild animal populations from the Caucasus Mountains east across southern and central Russia, to Kazakhstan, Mongolia, and parts of China; in Southwest and Southeast Asia, Southern and East Africa (including the island of Madagascar); in North America, from the Pacific Coast eastward to the western Great Plains, and from British Columbia south to Mexico; and in South America in two areas: the Andes mountains and Brazil. There is no plague-infected animal population in Europe or Australia. Globally, the World Health Organization reports 1,000 to 3,000 human cases of plague every year. On 2005-09-15, ABC News reported[http://abcnews.go.com/Health/story?id=1128953] that three mice infected with the bacteria responsible for bubonic plague apparently disappeared from a laboratory. The mice were unaccounted-for at the Public Health Research Institute, which is on the campus of the University of Medicine and Dentistry of New Jersey and conducts bioterrorism research for the United States federal government.

References

- de Carvalho, Raimundo Wilson; Serra-Freire, Nicolau Maués; Linardi, Pedro Marcos; de Almeida, Adilson Benedito; and da Costa, Jeronimo Nunes (2001). [http://memorias.ioc.fiocruz.br/965/4152.html Small Rodents Fleas from the Bubonic Plague Focus Located in the Serra dos Órgãos Mountain Range, State of Rio de Janeiro, Brazil]. Memórias do Instituto Oswaldo Cruz 96(5), 603–609. PMID 11500756. this manuscript reports a census of potential plague vectors (rodents and fleas) in a Brazilian focus region (i.e. region associated with cases of disease); free PDF download Retrieved 2005-03-02
- Gregg, Charles T. Plague!: The shocking story of a dread disease in America today. New York, NY: Scribner, 1978, ISBN 0684153726.
- Kelly, John. The Great Mortality: An Intimate History of the Black Death, the Most Devastating Plague of All Time. New York: HarperCollins Publishers Inc., 2005. ISBN 0060006927.
- McNeill, William H. Plagues and People. New York: Anchor Books, 1976. ISBN 0385121229.
- Orent, Wendy. Plague: The Mysterious Past and Terrifying Future of the World's Most Dangerous Disease. New York: Free Press, 2004. ISBN 0743236858.
- Patrick, Adam. "Disease in Antiquity: Ancient Greece and Rome," in Diseases in Antiquity, editors: Don Brothwell and A. T. Sandison. Springfield, Illinois; Charles C. Thomas, 1967.
- Simpson, W. J. A Treatise on Plague. Cambridge, England: Cambridge University Press, 1905.
- Speilvogal, Jackson J. Western Civilization: A Brief History Vol. 1: to 1715. Belmont, Calif.: West/Wadsworth, 1999, Ch. 3, p. 56, paragraph 2. ISBN 0534560628.
- ABC News, [http://abcnews.go.com/Health/story?id=1128953 Plague Infected Mice Missing From N.J. Lab], 2005-09-15

In literature

- The Decameron by Giovanni Boccaccio (1350). Takes place in Florence in 1348, during the outbreak of the "Black Death", widely believed to be Bubonic Plague.
- The Plague by Albert Camus (1947). An existentialist novel centered around an outbreak of the plague.
- A Journal of the Plague Year by Daniel Defoe (1722). A fictional first hand account of the London outbreak of 1665.
- Doomsday Book by Connie Willis (1992). A Hugo award and Nebula award-winning historical science fiction novel, in which a time-traveler inadvertently ends up in the plague-ridden England of 1348.

External links

- World Health Organization
- [http: